The Bermondsey boxer emerged victorious after a gruelling battle with American Carson Jones (40-13-3) to claim a unanimous points decision at The O2 on the undercard of Lawrence Okolie v Isaac Chamberlain on February 3.
The 22-year-old unbeaten super-welterweight, now with a record of 13-0, was pushed all the way in what was far and above his biggest and most testing challenge to date, taking the verdict with scores of 100-89 and 99-91 twice.
Oklahoma City's Jones, 31, who has upset Brit's Brian Rose and Ben Hall before, was heavy-handed and dangerous throughout the 10-round championship contest.
The Millwall FC fan tried to establish his jab and dominance early on but was soon forced to stand and trade with his travelling opponent, who was deducted a point in the penultimate round for repeated low blows.
Upon winning, Cheeseman bagged the vacant WBA International super-welterweight title in victory, his second major title in the pro ranks - last July he beat Matthew Ryan to win the English super-welterweight belt at the same venue along the Greenwich Peninsula.
Post-fight, he said: "At times I thought I could get him out of there, but I know he's a good fighter.
"I thought I boxed exceptionally well and got the job done perfectly. I know I had him hurt, this win is a career changer for me, it will push me on to big things.
"Tonight was about winning. I'm so happy with what I've done and I can't wait for my next big fight or big show."